Pub. Date : 2012 Apr
PMID : 22342521
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hephaestin (Heph) is a ferroxidase protein that converts ferrous to ferric iron to facilitate cellular iron export by ferroportin. | Iron | hephaestin | Mus musculus |
| 2 | In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear. | Iron | hephaestin | Mus musculus |
| 3 | In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear. | Iron | hephaestin | Mus musculus |
| 4 | Loss of both Heph and Cp from RPE cells alone results in RPE cell iron accumulation and degeneration. | Iron | hephaestin | Mus musculus |
| 5 | Photoreceptor-specific Heph knockout indicates that the additional iron in the RPE cells does not result from loss of ferroxidases in the photoreceptors, and Cp and Heph play minor roles in photoreceptors. | Iron | hephaestin | Mus musculus |
| 6 | Cp and Heph are necessary for iron export from the retina but are not essential for iron import into the retina. | Iron | hephaestin | Mus musculus |