Pub. Date : 1990 May-Jul
PMID : 2233817
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The levels of the messenger RNAs for the cytochromes P450IA1 (CYPIA1) and P450IA2 (CYPIA2) were determined in liver cytoplasmic RNA of rats of various ages after maximal induction with either 3-methylcholanthrene or isosafrole and in untreated rats. | isosafrole | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | An increase in the CYPIA1 mRNA levels was observed only after treatment with 3-methylcholanthrene, whereas both 3-methylcholanthrene and isosafrole were able to induce the levels of CYPIA2 mRNA. | isosafrole | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | After induction with isosafrole the levels of the CYPIA2 mRNAs in the older age groups were lower than those observed in young rats. | isosafrole | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |