Pub. Date : 2012 Mar 5
PMID : 22335402
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) at the blood-brain barrier: a case study examining sorafenib efflux clearance. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | The brain efflux index method, combined with the organotypic brain slices, was used to determine the net contribution of P-gp and BCRP to the total clearance of sorafenib out of the brain and show that its efflux at the BBB is mediated primarily by BCRP. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | The brain efflux index method, combined with the organotypic brain slices, was used to determine the net contribution of P-gp and BCRP to the total clearance of sorafenib out of the brain and show that its efflux at the BBB is mediated primarily by BCRP. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | Sorafenib clearance out of the brain decreased 2-fold in the Bcrp1(-/-) mice and 2.5-fold in the Mdr1a/1b(-/-)Bcrp1(-/-) mice. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 5 | Sorafenib clearance out of the brain decreased 2-fold in the Bcrp1(-/-) mice and 2.5-fold in the Mdr1a/1b(-/-)Bcrp1(-/-) mice. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 6 | In conclusion, this study explains the cooperation of P-gp and BCRP by analysis of the efflux clearance of sorafenib and correlating it to the "mechanisms" that determine the clearance, i.e., affinity and capacity. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |