Title : A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology.

Pub. Date : 2012 Feb

PMID : 22334892






1 Functional Relationships(s)
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1 Mutant Htt also hinders glutamate uptake from the synaptic cleft by down-regulating ERK-dependent expression of glutamate transporters, leaving cells vulnerable to excitotoxicity. Glutamic Acid mitogen-activated protein kinase 1 Homo sapiens