Pub. Date : 2012 Mar 1
PMID : 22333588
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently envisioned that intervention strategies aimed at reversing the bioenergetic signature of cancer cells (e.g., the antidiabetic biguanide metformin) should correct oncogene (e.g., HER2)-driven MHC-I defects, thus preventing immune escape of oncogene transformants. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | First, we explored how metformin treatment impacted mitochondrial biogenesis in cultured breast cancer cells overexpressing the membrane tyrosine kinase receptor HER2, the best-characterized downregulator of MHC-I. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |