Title : Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses.

Pub. Date : 2012 May

PMID : 22331493






9 Functional Relationships(s)
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1 Sodium arsenite +- hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. sodium arsenite tumor protein p53 Homo sapiens
2 In this study, we examined the role of p53 status in EOC response to a novel combination of cisplatin, sodium arsenite, and hyperthermia. sodium arsenite tumor protein p53 Homo sapiens
3 Human EOC cells were treated with cisplatin +- 20muM sodium arsenite at 37 C or 39 C for 1 h. Sodium arsenite +- hyperthermia sensitized wild-type p53-expressing (A2780, A2780/CP70, OVCA 420, OVCA 429, and OVCA 433) EOC cells to cisplatin. sodium arsenite tumor protein p53 Homo sapiens
4 P53 small interfering RNA (siRNA) transfection abrogated sodium arsenite sensitization effect. sodium arsenite tumor protein p53 Homo sapiens
5 Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells. sodium arsenite tumor protein p53 Homo sapiens
6 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite tumor protein p53 Homo sapiens
7 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite tumor protein p53 Homo sapiens
8 Hyperthermia +- sodium arsenite enhanced cellular and DNA accumulation of platinum in wild-type p53-expressing cells. sodium arsenite tumor protein p53 Homo sapiens
9 In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation. sodium arsenite tumor protein p53 Homo sapiens