Pub. Date : 2012 May
PMID : 22331493
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sodium arsenite +- hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 2 | In this study, we examined the role of p53 status in EOC response to a novel combination of cisplatin, sodium arsenite, and hyperthermia. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 3 | Human EOC cells were treated with cisplatin +- 20muM sodium arsenite at 37 C or 39 C for 1 h. Sodium arsenite +- hyperthermia sensitized wild-type p53-expressing (A2780, A2780/CP70, OVCA 420, OVCA 429, and OVCA 433) EOC cells to cisplatin. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 4 | P53 small interfering RNA (siRNA) transfection abrogated sodium arsenite sensitization effect. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 5 | Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 6 | XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 7 | XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 8 | Hyperthermia +- sodium arsenite enhanced cellular and DNA accumulation of platinum in wild-type p53-expressing cells. | sodium arsenite | tumor protein p53 | Homo sapiens |
| 9 | In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation. | sodium arsenite | tumor protein p53 | Homo sapiens |