Pub. Date : 2012 Mar 9
PMID : 22330808
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SIRT1 overexpression decreases cisplatin-induced acetylation of NF-kappaB p65 subunit and cytotoxicity in renal proximal tubule cells. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | While protein expression of SIRT1 was decreased by cisplatin treatment compared with control buffer treatment, acetylation of NF-kappaB p65 subunit was significantly increased after treatment with cisplatin. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Overexpression of SIRT1 ameliorated the increased acetylation of p65 of NF-kappaB during cisplatin treatment and cisplatin-induced cytotoxicity. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Further, treatment of cisplatin-treated HK2 cells with resveratrol, a SIRT1 activator, also decreased acetylation of NF-kappaB p65 subunit and cisplatin-induced increase of the cell viability in HK2 cells. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Our findings suggests that the regulation of acetylation of p65 of NF-kappaB through SIRT1 can be a possible target to attenuate cisplatin-induced renal cell damage. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |