Title : Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.

Pub. Date : 2012 Mar 1

PMID : 22326168






1 Functional Relationships(s)
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1 In addition to targeting these Aurora kinases involved in mitosis, CDK1 has been added as a primary inhibition target in hopes of enhancing the cytotoxicity of our chemotypes harboring the pyrazolopyrimidine core. 1H-pyrazolo[4,3-d]pyrimidine cyclin dependent kinase 1 Homo sapiens