Title : Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase.

Pub. Date : 2012 Feb

PMID : 22322891






1 Functional Relationships(s)
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1 These results suggest that mitochondrially bound HK supporting the ADP/ATP exchange activity levels facilitates the 3-BrPA inhibition reaction in tumors mitochondria by a proton motive force-dependent dynamic equilibrium between sensitive and less sensitive SDH in the electron transport system. Adenosine Diphosphate hexokinase 1 Homo sapiens