Title : Overexpression of tumor necrosis factor-α in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways.

Pub. Date : 2012 Apr

PMID : 22322299






1 Functional Relationships(s)
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1 Transgenic mice overexpressing TNF-alpha in type II alveolar epithelial cells under the control of the surfactant protein (SP)-C promoter develop pulmonary inflammation and emphysema but are resistant to induction of fibrosis by administration of bleomycin or transforming growth factor-beta. Bleomycin tumor necrosis factor Mus musculus