Title : Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

Pub. Date : 2012 Jul

PMID : 22318764






1 Functional Relationships(s)
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1 These studies indicate that the PPARalpha target gene UCP2 protects against elevated reactive oxygen species generated during drug-induced hepatotoxicity and suggest that induction of UCP2 may also be a general mechanism for protection of mitochondria during fatty acid beta-oxidation. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus