Pub. Date : 2012
PMID : 22312298
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also determined whether isoflurane modulates the expression and activity of sphingosine kinase-1 (SK1) and induces the phosphorylation of extracellular signal regulated kinase (ERK MAPK) as both enzymes are known to protect against cell death. | Isoflurane | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Mechanistically, isoflurane induces the phosphorylation of ERK MAPK and increased SK1 expression and activity in EA.hy926 cells. | Isoflurane | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Taken together, we demonstrate that isoflurane, in addition to its potent analgesic and anesthetic properties, protects against endothelial apoptosis most likely via SK1 and ERK MAPK activation. | Isoflurane | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Taken together, we demonstrate that isoflurane, in addition to its potent analgesic and anesthetic properties, protects against endothelial apoptosis most likely via SK1 and ERK MAPK activation. | Isoflurane | mitogen-activated protein kinase 1 | Homo sapiens |