Title : Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: role of the PSD-95/NR1/nNOS/PKCĪ³ signaling pathway.

Pub. Date : 2012 Apr 15

PMID : 22309983






3 Functional Relationships(s)
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1 Activation of the postsynaptic density protein-95 (PSD-95)/NMDAR-mediated downstream signaling cascade, including neuronal nitric oxide synthase (nNOS) and protein kinase gamma (PKCgamma), has been shown to be involved in morphine tolerance. Morphine protein kinase C, gamma Rattus norvegicus
2 The present study examined the potential effect of amitriptyline on chronic morphine infusion-induced spinal PSD-95/NMDAR/nNOS/PKCgamma signaling in morphine tolerance. Morphine protein kinase C, gamma Rattus norvegicus
3 Furthermore, amitriptyline co-infusion significantly inhibited morphine-induced PKCgamma expression in both the cytosol and membrane of spinal neurons. Morphine protein kinase C, gamma Rattus norvegicus