PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22309983-2	2012	Activation of the postsynaptic density protein-95 (PSD-95)/NMDAR-mediated downstream signaling cascade, including neuronal nitric oxide synthase (nNOS) and protein kinase gamma (PKCgamma), has been shown to be involved in morphine tolerance.	Morphine	222-230	protein kinase C, gamma	Rattus norvegicus	178-186	
22309983-3	2012	The present study examined the potential effect of amitriptyline on chronic morphine infusion-induced spinal PSD-95/NMDAR/nNOS/PKCgamma signaling in morphine tolerance.	Morphine	76-84	protein kinase C, gamma	Rattus norvegicus	127-135	
22309983-8	2012	Furthermore, amitriptyline co-infusion significantly inhibited morphine-induced PKCgamma expression in both the cytosol and membrane of spinal neurons.	Morphine	63-71	protein kinase C, gamma	Rattus norvegicus	80-88