Title : Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia.

Pub. Date : 2012 Apr 1

PMID : 22307138






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The Drug Metabolizing Enzymes and Transporters genotyping platform was applied to DNA obtained from six patients, which revealed the ABCC2-24C>T genotype cosegregated with sorafenib AUC phenotype. Sorafenib ATP binding cassette subfamily C member 2 Homo sapiens
2 CONCLUSIONS: This pilot study indicates that genotype status of UGT1A1, UGT1A9, and ABCC2 and serum bilirubin concentration increases reflect abnormally high AUC in patients treated with sorafenib. Sorafenib ATP binding cassette subfamily C member 2 Homo sapiens