Title : The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase.

Pub. Date : 2012 Jun

PMID : 22301273






4 Functional Relationships(s)
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1 The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase. Gangliosides ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Homo sapiens
2 We have recently established and characterized cellular clones deriving from MDA-MB-231 breast cancer cells that express the human G(D3) synthase (GD3S), the enzyme that controls the biosynthesis of b- and c-series gangliosides. Gangliosides ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Homo sapiens
3 We have recently established and characterized cellular clones deriving from MDA-MB-231 breast cancer cells that express the human G(D3) synthase (GD3S), the enzyme that controls the biosynthesis of b- and c-series gangliosides. Gangliosides ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Homo sapiens
4 Here, we show by mass spectrometry analysis of total glycosphingolipids that G(D3) and G(D2) are the main gangliosides expressed by the GD3S positive clones. Gangliosides ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Homo sapiens