Title : Melatonin enhances thapsigargin-induced apoptosis through reactive oxygen species-mediated upregulation of CCAAT-enhancer-binding protein homologous protein in human renal cancer cells.

Pub. Date : 2012 Aug

PMID : 22289049






4 Functional Relationships(s)
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1 Cotreatment with melatonin (1mm) and TG (50nm) induced approximately 10-fold expression levels of CCAAT-enhancer-binding proteins homologous protein (CHOP) compared with that of TG (50nm) alone. Thapsigargin DNA damage inducible transcript 3 Homo sapiens
2 Downregulation of CHOP expression using small interfering RNAs markedly attenuated melatonin plus TG-mediated apoptosis. Thapsigargin DNA damage inducible transcript 3 Homo sapiens
3 In addition, cotreatment with TG- and melatonin-induced CHOP upregulation likely relates to melatonin"s antioxidant capacity because we proved that this CHOP upregulation is melatonin receptor independent. Thapsigargin DNA damage inducible transcript 3 Homo sapiens
4 In addition, cotreatment with TG- and melatonin-induced CHOP upregulation likely relates to melatonin"s antioxidant capacity because we proved that this CHOP upregulation is melatonin receptor independent. Thapsigargin DNA damage inducible transcript 3 Homo sapiens