Pub. Date : 2012 May
PMID : 22288781
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure. | Sevoflurane | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | METHODS: Pheochromocytoma12 PC12 cells were exposed to 4.6% sevoflurane for 2 h. Subsequently, Western blotting was used to measure acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) 1/2 and basal Protein kinase B (AKT) phosphorylation. | Sevoflurane | mitogen activated protein kinase 3 | Rattus norvegicus |
| 3 | At 30 min after the end of sevoflurane administration [at 0.7% sevoflurane (0.102 mM)], ERK 1/2 phosphorylation remained reduced to 57 +- 7% (95% CI: 39-74%, P = 0.001) and was at 120 min [0.02% (0.003 mM] still reduced to 63 +- 10% (95% CI: 37-88%, P = 0.01), compared with control. | Sevoflurane | mitogen activated protein kinase 3 | Rattus norvegicus |
| 4 | At 30 min after the end of sevoflurane administration [at 0.7% sevoflurane (0.102 mM)], ERK 1/2 phosphorylation remained reduced to 57 +- 7% (95% CI: 39-74%, P = 0.001) and was at 120 min [0.02% (0.003 mM] still reduced to 63 +- 10% (95% CI: 37-88%, P = 0.01), compared with control. | Sevoflurane | mitogen activated protein kinase 3 | Rattus norvegicus |
| 5 | On one hand, we observed a prolonged attenuation of acetylcholine-induced ERK 1/2 phosphorylation that persisted even when sevoflurane concentrations close to detection level. | Sevoflurane | mitogen activated protein kinase 3 | Rattus norvegicus |