Title : The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats.

Pub. Date : 2012 Sep

PMID : 22288611






1 Functional Relationships(s)
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1 Rosuvastatin reduced hypertrophy significantly via AT(1) Receptor-PKCbeta2/alpha-ERK-c-fos pathway; protected myocardium against apoptosis via Akt-FOXO1, Bcl-2 family and survivin pathways and consequently suppressed the caspase-3 activity. Rosuvastatin Calcium Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus