Title : A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation.

Pub. Date : 2012 May

PMID : 22278941






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We showed that inactivation of FDPS by shRNA, small interfering RNA, or the highly specific pharmaceutical inhibitor alendronate inhibited beta2AR down-regulation. Alendronate adrenoceptor beta 2 Homo sapiens
2 Notably, in human airway smooth muscle cells, the physiological target of beta-agonists, alendronate treatment functionally reversed agonist-induced endogenous beta2AR loss as indicated by an increase in cAMP production. Alendronate adrenoceptor beta 2 Homo sapiens