Pub. Date : 2012 May
PMID : 22270849
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. | trichostatin A | tumor protein p53 | Homo sapiens |
| 2 | P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. | trichostatin A | tumor protein p53 | Homo sapiens |
| 3 | Characterizing the chromatin modulation around the p21(WAF1) promoter after TSA treatment using chromatin immunoprecipitation, we found (1) a release of HDAC1, (2) an increase of acetylated H4 binding, and (3) enhanced recruitment of p53. | trichostatin A | tumor protein p53 | Homo sapiens |
| 4 | Furthermore, TSA-treated p53-mutant cell line U138 failed to show an induction in p21(WAF1), showed a deficient G2/M checkpoint, and underwent mitotic catastrophe. | trichostatin A | tumor protein p53 | Homo sapiens |