Title : HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis.

Pub. Date : 2012 Jul 1

PMID : 22269210






2 Functional Relationships(s)
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1 Interestingly, Crizotinib (a dual inhibitor of c-Met and ALK pathways) as single agent or in combination with sunitinib reduced metastasis in all models tested suggesting a role for c-Met/HGF pathway in intrinsic- or sunitinib-induced-metastasis. Crizotinib met proto-oncogene Mus musculus
2 Interestingly, Crizotinib (a dual inhibitor of c-Met and ALK pathways) as single agent or in combination with sunitinib reduced metastasis in all models tested suggesting a role for c-Met/HGF pathway in intrinsic- or sunitinib-induced-metastasis. Crizotinib met proto-oncogene Mus musculus