Title : Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.

Pub. Date : 2012 Jan 22

PMID : 22266943






1 Functional Relationships(s)
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1 Whereas the overall structure of CYP17A1 provides a rationale for understanding many mutations that are found in patients with steroidogenic diseases, the active site reveals multiple steric and hydrogen bonding features that will facilitate a better understanding of the enzyme"s dual hydroxylase and lyase catalytic capabilities and assist in rational drug design. Hydrogen cytochrome P450 family 17 subfamily A member 1 Homo sapiens