Title : Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death.

Pub. Date : 2012 Mar

PMID : 22265823






3 Functional Relationships(s)
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Protein Name
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1 Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. puerarin AKT serine/threonine kinase 1 Homo sapiens
2 The presence of PI3K inhibitor LY294002 completely blocked puerarin-induced activation of Akt phosphorylation. puerarin AKT serine/threonine kinase 1 Homo sapiens
3 Collectively, these data suggest that the activation of PI3K/Akt pathway is involved in the protective effect of puerarin against MPP(+)-induced neuroblastoma SH-SY5Y cell death through inhibiting nuclear p53 accumulation and subsequently caspase-3-dependent PCD. puerarin AKT serine/threonine kinase 1 Homo sapiens