Title : Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation.

Pub. Date : 2012 Feb 10

PMID : 22252298






1 Functional Relationships(s)
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1 Together, CoQ10, selenite, and curcumin act as inhibitors of RANKL-induced NFATc1 which is a downstream event of NF-kappaB signal pathway through suppression of ROS generation, thereby suggesting their potential usefulness for the treatment of bone disease associated with excessive bone resorption. coenzyme Q10 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus