Title : High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.

Pub. Date : 2012 Apr

PMID : 22245600






3 Functional Relationships(s)
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1 High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-kappaB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. Reactive Oxygen Species mitogen-activated protein kinase 8 Rattus norvegicus
2 Mechanistic studies revealed that HG upregulated NADPH oxidase subunits p22(phox) and p47(phox) expression through JNK/NF-kappaB pathway, which resulted in elevation of NADPH oxidase activity and consequent ROS production. Reactive Oxygen Species mitogen-activated protein kinase 8 Rattus norvegicus
3 These results demonstrate that HG enhances mesangial cell proliferation and fibronectin expression through JNK/NF-kappaB/NADPH oxidase/ROS pathway, which was inhibited by resveratrol. Reactive Oxygen Species mitogen-activated protein kinase 8 Rattus norvegicus