Pub. Date : 2012 Jul
PMID : 22245234
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Maternal nicotine effects on vascular endothelial growth factor expression and morphometry in rat lungs. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | We evaluated the effects of maternal nicotine exposure on lung VEGF expression and morphometry during the postnatal period in rats. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | Nicotine exposure caused a significant decrease in vascular endothelial growth factor receptor (VEGFR)-2 mRNA expression, compared with the level of the control rats on Postnatal Day 1. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | CONCLUSIONS: Maternal nicotine exposure during pregnancy decreases VEGF and VEGFR-2 mRNA expression and alters lung structure in the lungs of postnatal rats. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 5 | Because angiogenesis is vital for alveolarization during normal lung development, these results suggest that decreased VEGF expression might be involved in the structural alterations of the developing lung after exposure to antenatal nicotine. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |