Title : Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARĪ± and CAR/PXR.

Pub. Date : 2012 Mar 11

PMID : 22245121






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Given the markedly lower or absent response of human hepatocytes to the proliferative stimulus from activation of PPARalpha and CAR/PXR, the hepatocellular proliferative response from activation of these receptors by PFOS observed in rats is not expected to be of human relevance. perfluorooctane sulfonic acid peroxisome proliferator activated receptor alpha Homo sapiens