Title : Ligand-based design of a potent and selective inhibitor of cytochrome P450 2C19.

Pub. Date : 2012 Feb 9

PMID : 22239545






1 Functional Relationships(s)
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1 Compound 30 exhibited improved metabolic stability (Cl(int) = 12.4 mL/min/nmol) and was selective in regard to inhibition of CYP2C19-catalyzed (S)-mephenytoin hydroxylation in human liver microsomes. Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens