Title : Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on anti-epileptic drug (phenytoin) absorption.

Pub. Date : 2012 Jun

PMID : 22239287






6 Functional Relationships(s)
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1 Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on anti-epileptic drug (phenytoin) absorption. Phenytoin ATP binding cassette subfamily B member 1 Homo sapiens
2 Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on anti-epileptic drug (phenytoin) absorption. Phenytoin ATP binding cassette subfamily B member 1 Homo sapiens
3 MDR1 C3435T gene polymorphism affects serum PHT levels (p<0.015). Phenytoin ATP binding cassette subfamily B member 1 Homo sapiens
4 Association of dose PHT ratio and genotype groups of MDR1 C3435T gene polymorphism showed a significant association (p<0.05). Phenytoin ATP binding cassette subfamily B member 1 Homo sapiens
5 MDR1*CC genotype was more common in cases with low serum PHT levels.In addition, it is evident that CT and TT genotype carriers have a high percentage of SR with elevated serum PHT levels. Phenytoin ATP binding cassette subfamily B member 1 Homo sapiens
6 MDR1*CC genotype was more common in cases with low serum PHT levels.In addition, it is evident that CT and TT genotype carriers have a high percentage of SR with elevated serum PHT levels. Phenytoin ATP binding cassette subfamily B member 1 Homo sapiens