Pub. Date : 2011 Oct
PMID : 22239058
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To detect the effect of p38 mitogen activated protein kinase (p38MAPK) and cyclooxygenase-2 (COX-2) on the expression of mucin5AC (MUC5AC) in human nasal mucosa induced by histamine in vitro, and to investigate the pathogenesis of mucus hypersecretion in allergic rhinitis (AR). | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 2 | OBJECTIVE: To detect the effect of p38 mitogen activated protein kinase (p38MAPK) and cyclooxygenase-2 (COX-2) on the expression of mucin5AC (MUC5AC) in human nasal mucosa induced by histamine in vitro, and to investigate the pathogenesis of mucus hypersecretion in allergic rhinitis (AR). | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 3 | METHOD: Western blot was performed to detect the protein expressions of p38MAPK, COX-2 and MUC5AC in nasal mucosa induced by histamine or blocked by selective inhibitors of p38MAPK and COX-2 of different concentration gradient. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 4 | COX-2 and MUC5AC increased in nasal mucosa induced by histamine in a dose-dependent manner. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 5 | The histamine induced protein expressions of COX-2 and MUC5AC were dose-dependently attenuated by selective inhibitor of COX-2, namely NS-398. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 6 | CONCLUSION: Our findings indicated that the histamine-induced increased expression of MUC5AC by activated p38MAPK/COX-2 may be a possible pathogenesis of mucus hypersecretion in AR. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |