PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22239058-1	2011	OBJECTIVE: To detect the effect of p38 mitogen activated protein kinase (p38MAPK) and cyclooxygenase-2 (COX-2) on the expression of mucin5AC (MUC5AC) in human nasal mucosa induced by histamine in vitro, and to investigate the pathogenesis of mucus hypersecretion in allergic rhinitis (AR).	Histamine	183-192	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	132-140	
22239058-1	2011	OBJECTIVE: To detect the effect of p38 mitogen activated protein kinase (p38MAPK) and cyclooxygenase-2 (COX-2) on the expression of mucin5AC (MUC5AC) in human nasal mucosa induced by histamine in vitro, and to investigate the pathogenesis of mucus hypersecretion in allergic rhinitis (AR).	Histamine	183-192	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	142-148	
22239058-2	2011	METHOD: Western blot was performed to detect the protein expressions of p38MAPK, COX-2 and MUC5AC in nasal mucosa induced by histamine or blocked by selective inhibitors of p38MAPK and COX-2 of different concentration gradient.	Histamine	125-134	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	91-97	
22239058-6	2011	COX-2 and MUC5AC increased in nasal mucosa induced by histamine in a dose-dependent manner.	Histamine	54-63	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	10-16	
22239058-7	2011	The histamine induced protein expressions of COX-2 and MUC5AC were dose-dependently attenuated by selective inhibitor of COX-2, namely NS-398.	Histamine	4-13	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	55-61	
22239058-11	2011	CONCLUSION: Our findings indicated that the histamine-induced increased expression of MUC5AC by activated p38MAPK/COX-2 may be a possible pathogenesis of mucus hypersecretion in AR.	Histamine	44-53	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	86-92