Pub. Date : 2012 Apr
PMID : 22235148
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 2 | Corresponding EC(50) values for the inhibition of SERT and NET based on unbound duloxetine spinal cord concentrations were 0.5 and 8 nM. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 3 | An effect compartment PK/PD modeling approach was used to analyze the relationship between the time course of duloxetine plasma concentration and SERT and NET occupancy. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |