Title : GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB.

Pub. Date : 2012 Mar

PMID : 22226621






1 Functional Relationships(s)
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1 What is more, the p38 inhibitor (SB203580) but not ERK1/2 inhibitor (PD98059) blocked LPS-induce NF-kappaB transactivation and ICAM-1 expression, which demonstrates that RhoA mediates LPS-induced NF-kappaB transactivation and ICAM-1 expression dominantly through p38 but not ERK1/2 activation. SB 203580 nuclear factor kappa B subunit 1 Homo sapiens