Title : N-3 long-chain polyunsaturated fatty acids inhibit smooth muscle cell migration by modulating urokinase plasminogen activator receptor through MEK/ERK-dependent and -independent mechanisms.

Pub. Date : 2012 Nov

PMID : 22221673






3 Functional Relationships(s)
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1 This study investigated the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the MEK/ERK pathway and urokinase plasminogen activator receptor (uPAR) in relation to SMC migration. Docosahexaenoic Acids mitogen-activated protein kinase 1 Homo sapiens
2 DHA also inhibited the activation of the MEK/ERK signaling pathway, whereas EPA switched the SMC phenotype from synthetic to contractile. Docosahexaenoic Acids mitogen-activated protein kinase 1 Homo sapiens
3 Our results suggest that n-3 LCPUFAs decrease SMC migration through the inhibition of uPAR expression, with DHA affecting its expression via the modulation of MEK/ERK signaling pathway, while EPA induces a change in SMC phenotype. Docosahexaenoic Acids mitogen-activated protein kinase 1 Homo sapiens