Title : Mechanisms involved in CD4 cell gains in HIV-infected patients switched to raltegravir.

Pub. Date : 2012 Mar 13

PMID : 22210634






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mechanisms involved in CD4 cell gains in HIV-infected patients switched to raltegravir. Raltegravir Potassium CD4 molecule Homo sapiens
2 At 6 months, mean CD4 cell counts significantly increased in raltegravir patients from 322 to 448 cells/mul (P = 0.026) but not in controls (from 312 to 330 cells/mul; P = 0.813). Raltegravir Potassium CD4 molecule Homo sapiens
3 In raltegravir patients, however, the proportion of naive CD4 T cells significantly increased (P = 0.014) as well as CD38 expression in these cells (P = 0.036). Raltegravir Potassium CD4 molecule Homo sapiens
4 CONCLUSION: HIV patients with prolonged undetectable viremia on HAART experience more pronounced CD4 gains after raltegravir switching than keeping the same regimen. Raltegravir Potassium CD4 molecule Homo sapiens