Title : Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition.

Pub. Date : 2011 Dec 29

PMID : 22206574






1 Functional Relationships(s)
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1 The targeted receptor tyrosine kinase inhibitor sorafenib inhibited the key signaling molecule Erk, which was activated following the addition of own conditioned media, suggesting the existence of autocrine/paracrine growth stimulatory pathways. Sorafenib EPH receptor B2 Homo sapiens