Title : Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation.

Pub. Date : 2012 Feb 15

PMID : 22205714






2 Functional Relationships(s)
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1 Importantly, resistance also correlated with increased levels of RAS-GTP, and sequencing of RAS genes revealed a rare activating mutation in KRAS, resulting in a K117N change in the KRAS protein. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens
2 Importantly, resistance also correlated with increased levels of RAS-GTP, and sequencing of RAS genes revealed a rare activating mutation in KRAS, resulting in a K117N change in the KRAS protein. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens