Pub. Date : 2012 Feb
PMID : 22203737
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PKC inhibitor calphostin C (1 mumol/L) or the PKCalpha/beta inhibitor Go6976 (1 mumol/L) decreased furosemide-sensitive O(2) consumption in both groups, achieving values that did not differ between sham and diabetic. | Superoxides | protein kinase C, alpha | Rattus norvegicus |
| 2 | We conclude that NADPH oxidase and PKC (primarily PKCalpha) contribute to an increase in O(2) consumption by the mTAL during type 1 diabetes through effects on the ouabain-sensitive Na(+)-K(+)-ATPase and furosemide-sensitive Na(+)-K(+)-2Cl(-) cotransporter that are primarily responsible for active transport Na(+) reabsorption by this nephron segment. | Superoxides | protein kinase C, alpha | Rattus norvegicus |