Protein Name protein kinase C, alpha
Organism Rattus norvegicus
Gene ID 24680
Gene Symbol

Prkca

UniProt B5DFC4 (B5DFC4_RAT), F1LS98 (F1LS98_RAT)
Relationships Total Number of functionally related compound(s) : 523
Total Number of Articles : 714
Description

protein kinase C, alpha

Gene Summary

Enables calcium-dependent protein kinase C activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and regulation of vesicle-mediated transport. Located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • protein kinase C alpha type
  • PKC-A
  • PKC-alpha
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Properties