Pub. Date : 2012 Jan 25
PMID : 22197970
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidant/detoxifying defense system related to glutathione (GSH) by p38 in HepG2 cells. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 6 | Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 7 | Quercetin (50muM) induced a time-dependent activation of p38, which was in concert with a transient stimulation of Nrf2 to provoke its inhibition afterward. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 8 | In conclusion, p38-MAPK is involved in the mechanisms of the cell response to quercetin through the modulation of Nrf2 and glutathione-related enzymes in HepG2 cells. | Quercetin | mitogen-activated protein kinase 14 | Homo sapiens |