Pub. Date : 2012 Feb 29
PMID : 22193059
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ). | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 2 | The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 3 | However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation. | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 4 | However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation. | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 5 | However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation. | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 6 | PQQ inhibited the activation of nuclear factor of activated T cells (NFATc1), a key transcription factor of osteoclastogenesis, in RANKL-stimulated cells. | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 7 | Taken together, PQQ was suggested to prevent RANKL-induced osteoclast formation via the inactivation of NFATc1 by reduced c-Fos expression. | PQQ Cofactor | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |