Title : The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.

Pub. Date : 2012 Mar

PMID : 22179221






2 Functional Relationships(s)
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1 RESULTS: GW501516 prevented IL-6-dependent reduction in insulin-stimulated v-akt murine thymoma viral oncogene homologue 1 (AKT) phosphorylation and in IRS-1 and IRS-2 protein levels. GW 501516 interleukin 6 Mus musculus
2 Moreover, GW501516 prevented IL-6-dependent induction of extracellular-related kinase 1/2 (ERK1/2), a serine-threonine protein kinase involved in serine STAT3 phosphorylation; the livers of Pparbeta/delta-null mice showed increased Tyr705- and Ser727-STAT3 as well as phospho-ERK1/2 levels. GW 501516 interleukin 6 Mus musculus