Title : Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled.

Pub. Date : 2011 Dec

PMID : 22179180






2 Functional Relationships(s)
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1 Because sorafenib inhibits C-Raf more potently than B-Raf, the therapeutic efficacy of sorafenib is strongly influenced by the relative expression and activity of B-Raf and C-Raf and the complex interactions between these factors. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens
2 Because sorafenib inhibits C-Raf more potently than B-Raf, the therapeutic efficacy of sorafenib is strongly influenced by the relative expression and activity of B-Raf and C-Raf and the complex interactions between these factors. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens