Pub. Date : 2012 Jan 25
PMID : 22178124
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was found that bufalin, cinobufagin, and resibufogenin were novel CYP3A4 inducers. | cinobufagin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Among them, bufalin and cinobufagin significantly promoted the CYP3A4 enzyme activity, mRNA and protein levels, with the maximal induction challenging or exceeding that of the induction by rifampicin, indicating that they might play a critical role in CYP3A4 enzyme-inducing effects of SBP. | cinobufagin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Among them, bufalin and cinobufagin significantly promoted the CYP3A4 enzyme activity, mRNA and protein levels, with the maximal induction challenging or exceeding that of the induction by rifampicin, indicating that they might play a critical role in CYP3A4 enzyme-inducing effects of SBP. | cinobufagin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |