Title : Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors.

Pub. Date : 2011

PMID : 22174910






1 Functional Relationships(s)
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1 Considering the role of RAS and RAF as downstream signals of both the EGFR and VEGFR pathways, we treated resistant cells with sorafenib, an inhibitor of C-RAF, B-RAF, c-KIT, FLT-3, RET, VEGFR-2, VEGFR-3, and PDGFR-beta. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens