Title : Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells.

Pub. Date : 2012 Feb 3

PMID : 22174412






1 Functional Relationships(s)
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1 Thus, the effects of these 17-HASs on AR signaling are complex, ranging from a decrease in testosterone production through the inhibition of Cyp17 as previously described, to directly reducing both AR protein expression and R1881-induced AR trans-activation. 17-hass cytochrome P450 family 17 subfamily A member 1 Homo sapiens