Pub. Date : 2012 Feb
PMID : 22170708
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CONTEXT: Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is active in castration-resistant prostate cancer. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | CONTEXT: Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is active in castration-resistant prostate cancer. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | RESULTS: Treatment with single-agent abiraterone acetate was associated with accumulation of steroids with mineralocorticoid properties upstream of CYP17A1. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | CONCLUSION: CYP17A1 inhibition with abiraterone acetate is characterized by significant suppression of androgen and cortisol synthesis. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |