Title : Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.

Pub. Date : 2012 Feb 3

PMID : 22167199






2 Functional Relationships(s)
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1 Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a beta2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells. Calcium adrenoceptor beta 2 Homo sapiens
2 Pharmacological inhibition and/or siRNA-mediated silencing of various signaling actors acting downstream of beta2ADR in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-trisphosphate (IP(3))/IP(3) receptor, were next demonstrated to prevent B(a)P-induced calcium signal. Calcium adrenoceptor beta 2 Homo sapiens