Title : Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells.

Pub. Date : 2012 Jan

PMID : 22150679






2 Functional Relationships(s)
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1 The proteins of HIF-1alpha, VEGF and RTP801 were significantly increased by dexmedetomidine treatment. Dexmedetomidine hypoxia inducible factor 1 subunit alpha Rattus norvegicus
2 CONCLUSIONS: Dexmedetomidine activated the I2 imidazoline receptor-PI3K/AKT pathway, and up-regulated HIF-1alpha, VEGF and RTP801 expression to protect against OGD-induced injury in rat C6 cells. Dexmedetomidine hypoxia inducible factor 1 subunit alpha Rattus norvegicus